For patients

# A targeted, oral therapy designed around patients

Zent-001 is an investigational medicine being studied for its potential to give physicians and patients a targeted, non-chemotherapy option — taken as a pill at home, not as an infusion at a clinic.

Find a clinical trial → Patient FAQ

How it works

## Three steps, designed for everyday life

From screening to daily dosing — here's what the journey could look like.

1. 01

   ### Biomarker screening

   A tissue sample is tested for Cyclin E1 amplification to see if the therapy may be a match.

2. 02

   ### Physician discussion

   If eligible, your care team reviews whether a Zentia clinical trial is the right next step for you.

3. 03

   ### Oral, once-daily dosing

   Take a pill at home each day — no infusion visits, with regular check-ins with your study team.

At a glance What sets it apart Targeted mechanism · Biomarker-matched · Oral dosing

Why it's different

## Designed to interrupt the cancer's survival plan

Cancer cells multiply quickly and make mistakes. They rely on a checkpoint protein called WEE1 to survive. Zent-001 blocks that checkpoint, pushing cancer cells past a point of no return.

Because it's matched to tumor biology and taken orally, the therapy is designed to be more convenient than infusion-based care — fewer trips, fewer disruptions to daily life.

- Not a chemotherapy — a targeted kinase inhibitor
- Oral, once-daily, at-home administration
- Developed with a companion diagnostic

Learn about trials → Common questions

Important considerations

## What to discuss with your care team

!

> Zent-001 is investigational and not approved by any health authority. There are risks with any medicine, including side effects. Your care team can help you weigh whether a clinical trial is right for you.

— Always discuss your options with your oncologist first
Available to discuss

### Support for patients

Our patient information team can help you understand eligibility, connect with a participating site, and answer questions about what participation involves.

Contact the team →
For physicians

### Information for healthcare professionals

Physicians can contact medical affairs for trial details, eligibility criteria and how to refer patients to participating sites.

Medical information →