Clinical development

# Programs built on WEE1 biology

A focused, late-stage clinical portfolio led by our biomarker-driven, oral WEE1 inhibitor across patient populations with significant unmet need.

Explore trial participation → Pipeline overview

By indication

## Explore each program

Phase 3 · ASPENOVA

### Cyclin E1-positive platinum-resistant ovarian cancer

Evaluating the first oral, non-chemotherapy, biomarker-driven approach for this patient population — transforming decades of WEE1 research into a novel targeted option.

Find a trial → Speak with our team

- Design Registration-intent, global
- Patient marker Cyclin E1 positive
- Comparator Standard-of-care
- Dosing Oral, once daily
- Status Enrolling

Phase 2 · Registration-intent

### Uterine serous carcinoma

A differentiated, biomarker-defined target population with a significant unmet need. Our program is designed to generate registration-intent evidence in parallel with the lead indication.

Find a trial → Speak with our team

- Design Registration-intent, global
- Patient marker Biomarker-defined
- Comparator Standard-of-care
- Dosing Oral, once daily
- Status Advancing

Preclinical · Phase 1

### Expanding the platform

Extending WEE1 biology into additional tumor types and rational combination strategies — building a durable franchise of targeted options across the oncology landscape.

Our science → Speak with our team

- Scope Multiple indications
- Combinations Rational, biomarker-led
- Dosing Oral, once daily
- Status Exploring

Development journey

## How our programs move forward

1. 01

   ### Discovery

   Deep mechanistic biology of cell-cycle control pinpoints novel, druggable targets.

2. 02

   ### Preclinical

   Compound selection, biomarker validation and registration-ready study design.

3. 03

   ### Clinical development

   Global, biomarker-driven trials advancing from first-in-human to registration.

4. 04

   ### Patient impact

   An oral, convenient therapy designed to unburden patients and their families.

For patients Thinking about a clinical trial? Find trial sites near you and learn what to expect at every step.

Patient participation

## Trials designed with patients in mind

Participation is a personal decision. Our team is here to help you understand what a trial involves — from screening to the final study visit.

Always speak with your care team first. If a Zentia trial could be right for you, we'll connect you with the study team to confirm eligibility and answer every question.

- Companion diagnostic screening at participating sites
- Oral therapy — no infusion visits required
- Support resources for patients and caregivers

Explore clinical trials → Read the FAQ